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The manufacturers claim it to be more effective with fewer side effects than previous second-generation drugs; however, there have been no published studies supporting this assertion.

A study part-funded by the manufacturer UCB concluded it may be more effective than some other second- and third-generation anti-histamines, but didn't compare it to cetirizine.

" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.

This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.

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"Very well," replied Ralph, going to a table and mixing a sedative that had been used under Doctor Rowe's orders.

They increase tractability and compliance of children or troublesome or demanding patients.

Although the drug was only authorized by the FDA on , it was already available in most European countries.

Like many new drugs it entered the market at a higher price than currently available third and second generation antihistamines.

Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.

"We're not saying that there's not a difference," says lead researcher Bruce G.